Drug-Induced Mitochondrial Dysfunction

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This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access. Pessayre D Role of reactive metabolites in drug-induced hepatitis.


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J Hepatol , SI Google Scholar. Diterpenoids from germander, a herbal medicine, induce apoptosis in isolated rat hepatocytes.

New Insights in Drug-Induced Mitochondrial Toxicity

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Am J Physiol , G - Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. Tianeptine, a new tricyclic antidepressant metabolized by 3-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem Pharmacol , - Amiodarone inhibits the mitochondrial 3-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther , - 6. Dual effect of amiodarone on mitochondrial respiration.

Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. Inhibition by perhexilline of oxidative phosphorylation and the 3-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions.

Mitochondria control of physiology and disease: beyond ATP

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Measurement of pH changes (Extracellular) in Mitochondria

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Antimicroh Agents Chemother , - Moyle G Abstract Background: Propylthiouracil PTU administration is associated with several cases of hepatotoxicity, especially in children. Metrics Comments Statistics. First Name. Required Valid Email address. Invaid Code Generate New Image. Abstract View: Your browser does not support the canvas element.

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